Federal State Budgetary Institution "Research Institute of Biomedical Chemistry named after V. Orekhovich" of the Russian Academy of Medical Sciences (FSBI "IBMH" RAMS). Biomedical Chemistry, Institute of Biomedical Chemistry, Institute of Biomedical Chemistry

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Chemical technology and biotechnology, Chemistry

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Full-time, Part-time, Part-time

Form of study:

No. 0004 series 90Л01 No. 0000004 valid from 05/29/2012 indefinitely

Licenses:

state standard

Certificate of completion:

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Department of Proteomic Research and Mass Spectrometry, Department of Bioinformatics, Department of Personalized Medicine, Scientific Laboratories, Department of Nanomedicines

Divisions:

University characteristics

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general information

FSBI "IBMH" RAMS conducts medical and biological research in the following areas:
Identification of biomarkers for risk prediction and early diagnosis of socially significant diseases using post-genomic technologies (personalized medicine)
Development of molecular detectors, reagents, algorithms and laboratory protocols to create new methods of medical diagnostics
Search for molecular targets, design and study of physiologically active substances, creation of drug transport systems

The staff number is 182 employees, of which 169 are scientific workers (29 doctors of sciences, 82 candidates of sciences).

The Institute's cumulative H-index for 2011, according to Web of Science, is 32.

Areas of expertise: biochemistry and medicinal chemistry, transcriptomics, proteomics and metabolomics, nanobiotechnology, cell and systems biology, bioinformatics.

The Institute is an educational and research base for students of the Medical and Biological Faculty of the Russian National Research Medical University.

It was created in 1944 as the Institute of Biological and Medical Chemistry of the USSR Academy of Medical Sciences on the basis of the departments of biochemistry and organic chemistry of the All-Union Institute of Experimental Medicine.

Modern name - since 1992. In 1944-1948. the institute was headed by academician Academy of Sciences of the SSR Ya.O. Parnas, in 1949-1989 - academician RAMS V.N. Orekhovich. Academicians worked at the institute. A.E. Braunstein, M.M. Shemyakin, S.E. Severin, N.A. Yudaev and other outstanding Russian biochemists.

The main research is related to the study of the structural and functional organization of biological macromolecules, mechanisms of intermolecular recognition during immune reactions, enzyme-substrate interactions, in reception processes, with the development of new methods of bioinformatics and computer-aided drug design, with the creation of tools for the diagnosis and treatment of the most common diseases; the hepatoprotector “Phosphogliv” has been developed and is being produced, intended for the treatment of liver diseases of various etiologies, including viral hepatitis (Russian Federation Government Prize in the field of science and technology (2003) for the creation of the domestic drug “Phosphogliv” for the treatment of liver diseases).

The Institute created the country’s first Department of Proteomic Research (2000) and the collective use center “Human Proteome” (from 2003 to 2010, the collective use center “Center for Postgenomic Technologies”), and publishes the scientific and practical journal “Biomedical Chemistry” (name until 2003 - “Issues of medicinal chemistry”). Since 2007, the highest-rated articles in the journal Biomedical Chemistry have been published in English as a supplement to the journal Biochemistry (Moscow) - Supplement Series B: Biomedical Chemistry.

The Institute is an educational and research base for undergraduate and graduate students.

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Basic scientific research programs of the Russian Academy of Medical Sciences for 2008-2012:
Study of the molecular mechanisms of the development of socially significant diseases using post-genomic technologies. (laboratory of diagnostic proteomics)
Development of a systematic approach to the analysis of living objects by combining methods of genomics, transcriptomics, metabolomics and bio- and chemoinformatics with mathematical data processing tools in order to identify molecular targets of drug action. (laboratory of systems biology and structural-functional design of drugs)
Development of original algorithms and computer programs for establishing relationships “amino acid sequence - structure - function” and predicting the functions of new proteins based on amino acid sequences. (lab. bioinformation technologies)
Development of fundamental and applied problems of nanopathology. (lab. nanobiotechnologies)
Search for new molecular targets for the pharmacological regulation of pathological processes in diseases of the central nervous system and cardiovascular system (lab. biochemistry of amines and cyclic nucleotides)
Development of experimental and computational approaches for the rational design of drugs and the creation of medicinal nanocompositions and nanomedicines (laboratory of phospholipid nanomedicines and transport systems)
Study of molecular genetic and biochemical mechanisms of neoplastic transformation and tumor progression, new molecular markers for diagnosis (lab. amine biosynthesis)
Topics of the IBMH RAMS within the framework of the RAMS program "Nanotechnologies and nanomaterials in medicine for the period 2008-2015":
Development of technologies for determining ultra-low concentrations of molecules using molecular detectors (laboratory of nanobiotechnology)
Development of medical diagnostic systems based on atomic force microscopy and nanoconducting materials (lab. nanobiotechnology)
Study of new drugs equipped with a transport system based on phospholipid nanoparticles (lab. phospholipid nanomedicines and transport systems)

The Institute was created in 1944 on the basis of the departments of biochemistry and organic chemistry of the VIEM. The first director of the Institute in 1944-1948. was academician Yakub Oskarovich Parnas. Academician Vasily Nikolaevich Orekhovich headed the Institute in 1949-1989. In recognition of his merits in the development of the Institute, in 1999 the Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences was named after V.N. Orekhovich. Since 1989, the Institute has been headed by Academician Alexander Ivanovich Archakov.
The country's largest biochemist scientists took part in the organization and development of the Institute: academicians A.E. Braunstein, M.M. Shemyakin, S.E. Severin, V.M. Rodionov, N.A. Yudaev, S.R. Mardashov, T.T. Berezov; corresponding members V.Z. Gorkin, B.F. Korovkin and I.I. Vautrin; Professor S.Ya. Kaplansky, G.L. Rosenfeld, G.Ya. Wiederschein, V.S. Tongur, T.S. Paskhina, and others. Many significant achievements of domestic biomedical science are associated with their names. In particular, A.E. Braunstein obtained fundamental data on the processes of enzymatic transamination and, in collaboration with Academician M.M. Shemyakin, created a general theory of pyridoxal phosphate-dependent reactions; V.N. Orekhovich et al. prolyl endopeptidase (EP 3.4.22.18), cathepsin R (EC 3.4.99.33) and dipeptidyl carboxypeptidase (angiotensin-converting enzyme, EC 3.4.15.1) were discovered and characterized; prof. I.S. Severina obtained fundamental results in deciphering the mechanism of regulation of the activity of aspartate transaminase, the most important enzyme of nitrogen metabolism.
A.I. Archakov is one of the world's leading experts in the field of microsomal oxidation. His work made a significant contribution to deciphering the structural-functional relationships of membrane proteins of the cytochrome P450 superfamily and to understanding the general mechanisms of intermolecular recognition. The results of scientific research obtained by A.A. Archakov et al. were awarded State Prizes: the USSR, the RSFSR and the Russian Federation.
As of January 1, 2004, the Institute employed 210 people, including 122 researchers, including 3 academicians of the Russian Academy of Medical Sciences, 7 professors, 26 doctors and 66 candidates of science.
The structure of the Institute includes a department of proteomic research, nine scientific laboratories, an academic group of Academician of the Russian Academy of Medical Sciences T.T. Berezov, research and production department and consultative and diagnostic clinic.
The Institute occupies a leading position in the country in such modern areas of biomedical research as:
- proteomics;
- bioinformatics;
- nanobiotechnologies.
Research and development are carried out by the Institute within the framework of projects of the International Scientific Foundations (ISTC, INTAS, CRDF, Wellcome Trust, Janssen Research Foundation, Royal Society, etc.), the Russian Foundation for Basic Research, the Russian Academy of Medical Sciences, the Ministry of Health of the Russian Federation, the Ministry of Industry and Science and technologies of the Russian Federation, the Moscow Committee on Science and Technology, as well as agreements and agreements on cooperation with various organizations.
In 2001, on the basis of the Institute, Russia’s first Center for Proteomic Research was created, working within the framework of the Interdepartmental Scientific and Technical Program “Proteomics for Medicine and Biotechnology” and a number of projects supported by the Ministry of Industry and Science of the Russian Federation, the Ministry of Health of Russia and the Russian Academy of Medical Sciences. Proteomic studies are associated with the inventory and study of post-translational modifications of proteins using the combined use of methods: two-dimensional electrophoresis, chromatography, mass spectrometric analysis of proteolytic fragments of proteins. Applied research is aimed at developing methods for diagnosing hepatitis and tumors, studying industrially important microorganisms, etc.
Using 2D-PAGE, MALDI-TOF mass spectrometry and separation on a SELDI chromatographic chip, it was established that the alpha chain of haptoglobin, apolipoprotein A-I, A-IV, orosomucoid are statistically reliable markers of ovarian cancer, and sulfated glycoprotein is a marker of breast cancer. The methods for analyzing membrane proteins developed in the department made it possible to obtain a proteomic map of liver microsomal proteins reflecting changes in protein expression during their drug induction. In order to study the variability of Helicobacter pylori strains, proteomic typing of isolates from different regions of Russia was carried out.
Employees of the proteomics department have developed computer programs and databases for analyzing complex mass spectra and identifying marker proteins on proteomic maps, as well as an educational program on a proteomics course to improve the skills of researchers working in the field of biochemistry and molecular biology.
Work in the field of bioinformatics is aimed at creating an integrated platform covering the entire chain of research “from genomes to drugs in silico”, which solves the following problems: (1) identification of target macromolecules based on genomic and proteomic data; (2) validation of the found targets using computer and experimental methods; (3) identification of the most promising basic structures of new drugs; (4) optimization of basic drug structures. The basic structures of new drugs identified using bioinformatics methods are tested in in vitro and in vivo experiments. The practical result of these studies was: identification of the most promising targets for creating drugs against Mycobacterium Tuberculosis; selection of immunogenic peptides in the hepatitis C virus polyprotein for the creation of vaccine constructs; design of new highly selective monoamine oxidase A inhibitors as potential antidepressants; discovery of original anxiolytics and nootropics with a high degree of novelty of chemical structure, identification of antihypertensive substances with combined mechanisms of action, etc. The Institute is developing nanobiotechnological approaches that have several orders of magnitude higher sensitivity and speed compared to currently used standard analysis methods. These include methods based on the use of optical nanostructured biosensors coupled with mass spectrometers and atomic force microscopes, which make it possible to detect, concentrate and identify functionally significant biomacromolecules in biological fluids, in a wide range of concentrations (from micro- to attomoles).
Every year, the Institute’s staff publishes 50-80 scientific articles in domestic and international scientific journals; Over the last decade, 19 Russian and 2 international patents have been received.
A new drug for the treatment of chronic liver diseases of various etiologies, PHOSPHOGLIV (capsule and injection forms), has been developed and introduced into medical practice. In order to organize the production of this drug, the building at the Institute was reconstructed and a production site was organized.
The Scientific Council of the Russian Academy of Medical Sciences and the Ministry of Health of the Russian Federation on biomedical chemistry operates on the basis of the Institute, in which 11 research organizations participate.
The Institute operates a system of personnel training through competition and postgraduate studies in the specialty “biochemistry”; There is a dissertation council for the defense of dissertations for the degree of doctor and candidate of biological and medical sciences in the specialty “biochemistry”. Over the past decade, 8 doctoral and 52 candidate dissertations have been defended.
The Institute is an educational and research base for undergraduates, graduates and graduate students from the Moscow Philosophy of the Russian State Medical University, MMA named after. THEM. Sechenov, MEPhI, MIPT and other universities in Moscow, which carry out coursework, diploma and dissertation work here using post-genomic technologies. The Institute’s staff takes part in giving lectures and conducting seminars for students of the ICF RSMU, MGSA and MAPO.
The Institute publishes the scientific journal “Biomedical Chemistry” (ISSN 0042-8809), which publishes works on all modern branches of biological and medicinal chemistry.
In recent years, the scientific achievements of the State Research Institute of Biochemistry of the Russian Academy of Medical Sciences have been awarded a number of awards: the State Prize of the Russian Federation in the field of science and technology for 1998 for the work “Microsomal oxidation and metabolism of drugs: the mechanism of oxygenase reactions catalyzed by cytochrome P450 and their modeling”, the Russian Government Prize Federation in the field of science and technology for 2002 for the creation of a domestic drug for the treatment of liver diseases “Phosphogliv”, two Prizes of the Presidium of the Russian Academy of Medical Sciences for the results obtained in the field of fundamental medical research.
Preserving the traditions of the national scientific school, laid down by academicians of the Russian Academy of Medical Sciences Ya.O. Parnas, V.N. Orekhovich, A.I. Archakov, and developing international scientific cooperation, the Institute is today one of the leading centers of biomedical science in Russia.

Material from Wikipedia - the free encyclopedia

Institute of Biomedical Chemistry named after V. N. Orekhovich RAMS (IBMH RAS)
Based
Director	Andrey Valerievich Lisitsa
Employees	270 people, including 178 scientists
Postgraduate studies
Location
Legal address	Story At different times, biochemist academicians A. E. Braunshtein, M. M. Shemyakin, S. E. Severin, N. A. Yudaev, S. R. Mardashev, T. T. Berezov worked at the institute; corresponding members V.Z. Gorkin, B.F. Korovkin and I.I. Votrin; professors S. Ya. Kaplansky, G. L. Rosenfeld, G. Ya. Widershain, V. S. Tongur, T. S. Paskhina. Field of scientific research proteomics; Proteomic studies are associated with the study of post-translational modifications of proteins. bioinformatics; Bioinformatics covers research from genomes to drugs and solves the following problems: identification of target macromolecules based on genomic and data; synthesis of new drugs. nanobiotechnology. Nanobiotechnologies use nanostructured biosensors that make it possible to determine functionally significant biomacromolecules in biological fluids. The Institute has developed the drug Phosphogliv, intended for the treatment of chronic liver diseases. Institute structure The institute includes departments of proteomic research and mass spectrometry, personalized medicine, nanomedicines, bioinformatics, scientific laboratories of protein biosynthesis, peptide engineering, microsomal oxidation, etc. Modernity Currently, the institute is working in the following areas: the use of biomarkers for early diagnosis of diseases, the development of molecular detectors, reagents for new methods for diagnosing diseases, the creation of drug transport systems in the human body. Proceedings The scientific works of the institute’s staff are published in the journal “Biomedical Chemistry” published by the institute (until 2003 - “Issues of medical chemistry”). Write a review of the article "Institute of Biomedical Chemistry named after V. N. Orekhovich" Links Notes Coordinates: 55°43′57″ n. w. 37°34′03″ W d. /  55.73250° N. w. 37.56750° W d. / 55.73250; -37.56750(G) (I) An excerpt characterizing the Institute of Biomedical Chemistry named after V. N. Orekhovich “I’m listening, Your Excellency,” Timokhin said, smiling, making it feel like he understood the boss’s wishes. - Yes Yes. The regimental commander found Dolokhov in the ranks and reined in his horse. “Before the first task, epaulets,” he told him. Dolokhov looked around, said nothing and did not change the expression of his mockingly smiling mouth. “Well, that’s good,” continued the regimental commander. “The people each have a glass of vodka from me,” he added so that the soldiers could hear. – Thank you everyone! God bless! - And he, overtaking the company, drove up to another. “Well, he’s really a good man; “You can serve with him,” said subaltern Timokhin to the officer walking next to him. “One word, the king of hearts!... (the regimental commander was nicknamed the king of hearts),” the subaltern officer said, laughing. The happy mood of the authorities after the review spread to the soldiers. The company walked cheerfully. Soldiers' voices were talking from all sides. - What did they say, crooked Kutuzov, about one eye? - Otherwise, no! Totally crooked. - No... brother, he has bigger eyes than you. Boots and tucks - I looked at everything... - How can he, my brother, look at my feet... well! Think… - And the other Austrian, with him, was as if smeared with chalk. Like flour, white. I tea, how they clean ammunition! - What, Fedeshow!... did he say that when the fighting began, you stood closer? They all said that Bunaparte himself stands in Brunovo. - Bunaparte is worth it! he's lying, you fool! What he doesn’t know! Now the Prussian is rebelling. The Austrian, therefore, pacifies him. As soon as he makes peace, then war will open with Bunaparte. Otherwise, he says, Bunaparte is standing in Brunovo! That's what shows that he's a fool. Listen more. - Look, damn the lodgers! The fifth company, look, is already turning into the village, they will cook porridge, and we still won’t reach the place. - Give me a cracker, damn it. - Did you give me tobacco yesterday? That's it, brother. Well, here we go, God be with you. “At least they made a stop, otherwise we won’t eat for another five miles.” – It was nice how the Germans gave us strollers. When you go, know: it’s important! “And here, brother, the people have gone completely rabid.” Everything there seemed to be a Pole, everything was from the Russian crown; and now, brother, he’s gone completely German. – Songwriters forward! – the captain’s cry was heard. And twenty people ran out from different rows in front of the company. The drummer began to sing and turned to face the songwriters, and, waving his hand, began a drawn-out soldier’s song, which began: “Isn’t it dawn, the sun has broken...” and ended with the words: “Then, brothers, there will be glory for us and Kamensky’s father...” This song was composed in Turkey and was now sung in Austria, only with the change that in place of “Kamensky’s father” the words were inserted: “Kutuzov’s father.” Having torn off these last words like a soldier and waving his hands, as if he was throwing something to the ground, the drummer, a dry and handsome soldier of about forty, looked sternly at the soldier songwriters and closed his eyes. Then, making sure that all eyes were fixed on him, he seemed to carefully lift with both hands some invisible, precious thing above his head, held it like that for several seconds and suddenly desperately threw it: Oh, you, my canopy, my canopy! “My new canopy...”, twenty voices echoed, and the spoon holder, despite the weight of his ammunition, quickly jumped forward and walked backwards in front of the company, moving his shoulders and threatening someone with his spoons. The soldiers, waving their arms to the beat of the song, walked with long strides, involuntarily hitting their feet. From behind the company the sounds of wheels, the crunching of springs and the trampling of horses were heard. Kutuzov and his retinue were returning to the city. The commander-in-chief gave a sign for the people to continue walking freely, and pleasure was expressed on his face and on all the faces of his retinue at the sounds of the song, at the sight of the dancing soldier and the soldiers of the company walking cheerfully and briskly. In the second row, from the right flank, from which the carriage overtook the companies, one involuntarily caught the eye of a blue-eyed soldier, Dolokhov, who especially briskly and gracefully walked to the beat of the song and looked at the faces of those passing with such an expression, as if he felt sorry for everyone who did not go at this time with the company. A hussar cornet from Kutuzov's retinue, imitating the regimental commander, fell behind the carriage and drove up to Dolokhov.

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Material from Wikipedia - the free encyclopedia

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Location
Legal address	Story At different times, biochemist academicians A. E. Braunshtein, M. M. Shemyakin, S. E. Severin, N. A. Yudaev, S. R. Mardashev, T. T. Berezov worked at the institute; corresponding members V.Z. Gorkin, B.F. Korovkin and I.I. Votrin; professors S. Ya. Kaplansky, G. L. Rosenfeld, G. Ya. Widershain, V. S. Tongur, T. S. Paskhina. Field of scientific research proteomics; Proteomic studies are associated with the study of post-translational modifications of proteins. bioinformatics; Bioinformatics covers research from genomes to drugs and solves the following problems: identification of target macromolecules based on genomic and data; synthesis of new drugs. nanobiotechnology. Nanobiotechnologies use nanostructured biosensors that make it possible to determine functionally significant biomacromolecules in biological fluids. The Institute has developed the drug Phosphogliv, intended for the treatment of chronic liver diseases. Institute structure The institute includes departments of proteomic research and mass spectrometry, personalized medicine, nanomedicines, bioinformatics, scientific laboratories of protein biosynthesis, peptide engineering, microsomal oxidation, etc. Modernity Currently, the institute is working in the following areas: the use of biomarkers for early diagnosis of diseases, the development of molecular detectors, reagents for new methods for diagnosing diseases, the creation of drug transport systems in the human body. Proceedings The scientific works of the institute’s staff are published in the journal “Biomedical Chemistry” published by the institute (until 2003 - “Issues of medical chemistry”). Write a review of the article "Institute of Biomedical Chemistry named after V. N. Orekhovich" Links Notes Coordinates: An excerpt characterizing the Institute of Biomedical Chemistry named after V. N. Orekhovich The girl, on the contrary, was cheerful and very active and seemed to feel completely happy in the world in which she currently lived. I couldn’t understand what was wrong here and tried to stay as calm as possible so as not to frighten off my strange guests. - Mom, mom, speak up!!! – Apparently the girl couldn’t stand it again. She looked no more than five or six years old, but apparently she was the leader in this strange company. The woman was silent the whole time. I decided to try to “melt the ice” and asked as gently as possible: - Tell me, can I help you with something? The woman looked at me sadly and finally said: – Can anyone help me? I killed my daughter!.. This confession gave me goosebumps. But this apparently did not bother the girl at all and she calmly said: - That's not true, mom. – What was it really like? – I asked carefully. “A terribly large car ran into us, and my mother was driving.” She thinks it's her fault that she couldn't save me. “The girl patiently explained in the tone of a little professor. “And now my mother doesn’t even want to live here, and I can’t prove to her how much I need her.” – And what would you like me to do? – I asked her. “Please, could you ask my dad to stop blaming mom for everything?” – the girl suddenly asked very sadly. “I’m very happy here with her, and when we go to see dad, she then becomes like she is now for a long time... And then I realized that the father apparently loved this little girl very much and, having no other opportunity to pour out his pain somewhere, blamed her mother for everything that happened. – Do you want this too? – I asked the woman softly. She just nodded sadly and again closed herself tightly in her sorrowful world, not letting anyone in, including her little daughter, who was already worried about her. – Dad is good, he just doesn’t know that we are still alive. – The girl said quietly. - Please tell him... There is probably nothing worse in the world than feeling the guilt that she felt... Her name was Christina. During her life, she was a cheerful and very happy woman, who, at the time of her death, was only twenty-six years old. Her husband adored her... Her little daughter’s name was Vesta, and she was the first child in this happy family, whom everyone adored, and her father simply doted on her... The head of the family himself was named Arthur, and he was the same cheerful, cheerful person as his wife was before her death. And now no one and nothing could help him find at least some peace in his pain-torn soul. And he grew in himself hatred for his loved one, his wife, trying to protect his heart from complete collapse. - Please, if you go to dad, don’t be scared of him... He can be strange sometimes, but that’s when he’s “not real.” – The girl whispered. And it was felt that she was unpleasant to talk about it. I didn’t want to ask and upset her even more, so I decided that I would figure it out myself. I asked Vesta which of them wants to show me where they lived before their death, and whether her father still lives there? The place they named upset me a little, since it was quite far from my home, and it took a lot of time to get there. That’s why I couldn’t think of anything right away and asked my new acquaintances if they could appear again at least in a few days? And having received an affirmative answer, I “iron” promised them that I would definitely meet with their husband and father during this time. Vesta looked at me slyly and said: – If dad doesn’t want to listen to you right away, you tell him that his “little fox” misses him very much. That's what dad called me only when we were alone, and no one else knows this except him... Her sly little face suddenly became very sad, apparently remembering something very dear to her, and she really became somewhat like a little fox... - Well, if he doesn’t believe me, I’ll tell him so. - I promised. The figures, flickering softly, disappeared. And I kept sitting in my chair, tensely trying to figure out how I could win at least two or three free hours from my family so that I could keep my word and visit my father, who was disappointed with his life...

Biomedical research is carried out at IBMH in the following areas:

• Identification of biomarkers for risk prediction and early diagnosis of socially significant diseases using post-genomic technologies (personalized medicine)
• Development of molecular detectors, reagents, algorithms and laboratory protocols to create new methods of medical diagnostics
• Search for molecular targets, design and study of physiologically active substances, creation of drug transport systems

Bioinformatics Department:

The IBMH Bioinformatics Department conducts research in the field of bioinformatics and computer-aided drug design. The presence of qualified specialists, original and commercially available software and databases, as well as high-performance computing resources allows us to carry out fundamental research and applied developments covering the entire chain “From genomes to drugs in silico”.

The Bioinformatics Department of IBMH currently includes five laboratories:

Bioinformation technologies (headed by Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences Andrei Valerievich Lisitsa).

Analysis of post-genomic data (headed by Elena Aleksandrovna Ponomarenko, PhD).

Structural and functional design of drugs (headed by Prof., Doctor of Biological Sciences, Candidate of Physical and Mathematical Sciences Vladimir Vasilievich Poroikov).

Structural bioinformatics (head - Doctor of Biological Sciences Alexander Vladimirovich Veselovsky).

Parallel computing and information technologies (head - Ph.D. Vladlen Stanislavovich Skvortsov).